Are you a skilled and motivated Biomedical or Clinical Scientist ready to elevate your career in an innovative environment? The Cambridge Cellular Therapy Laboratory (CCTL) offers a remarkable opportunity for a Band 7 Senior Healthcare Scientist to join our vibrant and expanding team in a maternity cover role.
Situated on the prestigious Cambridge Biomedical Campus--Europe's largest biomedical research hub--CCTL leads the way in cellular therapy. Our accredited laboratory is essential in analysing, processing, cryopreserving, and storing cells for therapeutic purposes. We are at the forefront of Immune Effector Cells and Advanced Therapy Medicinal Products (AT(I)MPs), including CAR-T cells for diverse clinical applications.
As we grow, CCTL will expand to a new, purpose-built facility in the cutting-edge Jeffrey Cheah Biomedical Centre (JCBC), featuring four advanced cleanrooms and enhanced capabilities for managing Class 1 and Class 2 genetically modified organisms (GMOs).
Collaborating with world-class experts and located near two flagship NHS trusts and leading research institutes, you will be part of a mission to deliver transformative therapies that impact lives.
If you are ready to take the next step in your career and help shape the future of cellular therapy, apply today to join the winning team at the Cambridge Cellular Therapy Laboratory.
Main duties of the job
In this role, you will be essential in overseeing the routine stem cell transplantation service, guided by the Associate Operations Manager and the Production Manager. You will champion compliance with regulations set by bodies like the Human Tissue Authority (HTA) and the Joint Accreditation Committee for ISCT & EBMT (JACIE), paving the way for transformative patient care.
Your expertise in Quality Management Systems will be vital as you engage in the reporting, investigation, and execution of Corrective and Preventive Actions (CAPA) in response to quality events. You will lead change management and validation projects, driving innovation and fostering a culture of continuous improvement within the laboratory.
In addition, you will:
* Supervise and mentor staff members, nurturing a positive leadership environment.
* Support the CAR T service and play a key role in developing new immunotherapies as they emerge.
* Leverage your theoretical and practical understanding of all phases of stem cell processing, enriching our mission.
* Manage and oversee operations within the Liquid Nitrogen facility.
* Work in a cleanroom environment, handling human blood and tissues with unwavering commitment to safety protocols.
* Contribute to role-specific duties, which may vary based on your registration status with the Health and Care Professions Council (HCPC).
About us
Cambridge University Hospitals (CUH) NHS Foundation Trust comprises Addenbrooke's Hospital and the Rosie Hospital in Cambridge. With over 13,000 staff and over 1100 beds the priorities of the Trust focus on a quality service which is all about people - patients, staff and partners. Recognised as providing 'outstanding' care to our patients and rated 'Good' overall by the Care Quality Commissioner, is testament to the skill and dedication of the people who work here. CUH's values - Together - Safe, Kind, Excellent - are at the heart of patient care, defining the way all staff work and behave.
CUH is committed to promoting a diverse and inclusive community - a place where we can all be ourselves. We value our differences and fully advocate and support an inclusive working environment where every individual can fulfil their potential. We want to ensure our people are truly representative of all the communities that we serve.
Job description
Job responsibilities
A background in fields such as Cell Therapy, Manufacturing, Pharmacy, Haematology with Transfusion, Immunology, or Histocompatibility and Immunogenetics will significantly enhance your impact in this position.
This is a unique opportunity to assume a leadership role in a cutting-edge facility, directly contributing to the future of cellular therapy and ground breaking treatments.
Please see the attached Applicant Information Pack (combined Job Description and Person Specification) for key duties and responsibilities.
Please note: Internal applicants on permanent contracts can only apply for this post as a secondment and must have the approval of your current line manager before applying.
This vacancy will close at midnight on 4th November 2024. Interviews are due to be held week commencing 18th November 2024.
What We Offer:
* A progressive and accredited laboratory focused on ground breaking cellular therapies.
* Opportunities to engage with advanced therapies and GMOs, including CAR-T cell provision.
* The chance to be involved in life-changing treatments within an expanding regional facility.
* A supportive and collaborative atmosphere within a leading biomedical research campus.
Person Specification
Qualifications
Essential
* Relevant BSc or equivalent.
* Relevant MSc or equivalent.
* Relevant HCPC registration.
Desirable
* IBMS specialist portfolio, completion of STP training or equivalent Cell Therapy specialist training programme.
* PhD.
Experience
Essential
* Experience in a laboratory such as Cell/Gene therapy, Blood Transfusion, Immunology, H& I, Pharmacy, or clinical manufacturing facility.
* Leadership / supervision of junior staff.
* Use of the laboratory information and quality management systems.
* Experience of change management, validation and designing workflows.
* Experience of pre-inspection audits or HTA/MHRA/JACIE inspection preparation and outcome management.
Desirable
* Experience of a HTA/MHRA licensed laboratory.
* Proven workflow/ capacity management.
* Working to cGMP.
* Use of Ultra Low Temperature storage.
* Experience of out of hours working.
* Experience of working in a Clean Room environment or aseptic technique.
Knowledge
Essential
* Awareness of Quality Regulations in relation to processing of cells and tissue for human application (HTA/MHRA/JACIE).
* Fully Computer literate.
* COSHH and Risk Assessment procedures.
* Awareness of the Good Laboratory Practice (GLP).
* Understanding of how to effectively manage and implement change.
Desirable
* Receipt, processing, cryopreservation, storage, issue of products for haematopoietic stem cell transplantation.
* Database literate.
* Q Pulse Quality Management System.
* Flow cytometry.
* Immunology.
* Cell/Gene Therapy.
* Awareness of genetically modified organisms.
Skills
Essential
* Excellent communication and interpersonal skills.
* Able to supervise and train junior staff.
* Ability to work in an organised manner, to high standards and with a very high level of accuracy and precision.
* Good time management.
* Ability to multi-task and prioritise.
* Ability to concentrate for long periods.
* The ability to problem solve and troubleshoot.
* Evidenced decision making skills with the potential for clinical impact.
* Scientific critical thinking skills.
Desirable
* Ability to cope under pressure.
* Presentation skills.
Additional Requirements
Essential
* The ability to understand and behave at all times, towards patients, visitors and colleagues according to the Trust values of Safe, Kind, Excellent.
Employer details
Employer name
Cambridge University Hospital NHS Foundation Trust
Address
Addenbrookes Hospital-Division B, Hills Road, Cambridge, CB2 0QQ
Any attachments will be accessible after you click to apply.
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