Background
Our interdisciplinary team at the Centre for Membrane Proteins and Receptors (COMPARE) brings together experts in advanced microscopy, computer vision/deep learning and cell signalling to clarify the mechanisms of cell communication in physiology and disease and inform the development of innovative therapies. As part of these efforts, we are developing highly innovative hardware and software for advanced microscopy and using them to investigate the mechanisms of receptor signalling with unprecedented detail. Using such approaches, including single-molecule methods pioneered by our team, we have clarified some of the fundamental mechanisms involved in signalling by G protein-coupled receptors (GPCRs), the largest family of cell receptors and major drug targets.
Role Summary
We are seeking a highly motivated scientist to join our interdisciplinary team at the University of Birmingham to develop "An AI-driven Automated Platform for High-Throughput 5D Fluorescence Imaging and Data Analysis Applied to Cell Signalling and Drug Discovery". The project is funded by a Wellcome Trust Bioimaging Technology Development Award (Foundation Phase) and is led by Prof. Davide Calebiro and Dr Hector Basevi, Department of Metabolism and Systems Science, Prof. Ales Leonardis, School of Computer Science, and Dr Edalat Radfar, COMPARE Advanced Imaging Facility.
The goal of the project is to develop a highly innovative fully automated microscopy and image analysis platform capable of generating large 5D datasets of living cells with high spatiotemporal resolution, use the data to extract quantitative information, and build generative models of cell signalling dynamics. We will apply the new platform to investigate how GPCR signals are encoded in space and time, addressing fundamental questions about GPCR signalling and unlocking novel avenues for drug development.
The position will be initially for up to 18 months. In October 2025, the project lead will apply for the Bioimaging Technology Development Scale-Up phase, which, if successful, could extend the project funding for up to an additional 6.5 years.
The successful candidate will be responsible for designing and performing the biological experiments aimed at clarifying how GPCR signals are encoded in space and time, collect the data to train the automation and analysis systems, analyse the imaging and modelling data and interpret the results. They will also contribute to the testing and validation of the platform as well as the design and testing of the user interfaces and image analysis tools.
Main Duties
* Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
* Contribute to writing bids for research funding
* Analyse and interpret data, applying knowledge in a way which develops new intellectual understanding
* Disseminate research findings for publication, research seminars, etc.
* Supervise students on research related work and provide guidance to PhD students
* Contribute to developing new models, techniques and methods
* Contribute to Departmental/School research-related activities
* Collect research data
* Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
* Provide guidance, as required, to support staff and any students who may be assisting with the research
* Deal with problems that may affect the achievement of research objectives and deadlines
* Promote equality and value diversity, acting as a role model and fostering an inclusive working culture.
Person Specification
* Bachelor’s and/or master’s degree in biology, biochemistry or related field and, normally, a PhD or equivalent qualifications on a relevant topic.
* High level analytical capability
* Ability to communicate complex information clearly
* Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
* Ability to assess resource requirements and use resources effectively
* Contribute to the planning and organising of the research programme and/or specific research project
* Co-ordinate own work with others to avoid conflict or duplication of effort
* Knowledge of mammalian cell culture and molecular biology techniques (cloning, transfection, etc.)
* Ideally, previous experience with GPCR signalling and/or live cell imaging and image analysis
* Enthusiasm for interdisciplinary experimental research and team work
* Drive to learn new skills
* Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day-to-day activity in own area that those with protected characteristics are treated equally and fairly.
Please note shortlisted candidates will be asked to give a 10 minute presentation on your current/previous research and how you would fit into the role.
We believe there is no such thing as a 'typical' member of University of Birmingham staff and that diversity in its many forms is a strength that underpins the exchange of ideas, innovation and debate at the heart of University life. We are committed to proactively addressing the barriers experienced by some groups in our community and are proud to hold Athena SWAN, Race Equality Charter and Disability Confident accreditations. We have an Equality Diversity and Inclusion Centre that focuses on continuously improving the University as a fair and inclusive place to work where everyone has the opportunity to succeed. We are also committed to sustainability, which is a key part of our strategy.
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