Studies of how genetic variants alter function have been historically hindered by limited means of genome editing. Now, CRISPR technologies present unprecedented opportunity to characterize human variants experimentally. Our lab drives progress in this area by developing high-throughput methods that enable us to test the effects of up to tens of thousands of variants per experiment.
With generous funding from Cancer Research UK, we are collaboratively studying 100,000s of human variants across more than 15 cancer susceptibility genes. In the near term, research led by the successful candidate will include developing new assays to functionally characterize variants in many of these genes. The successful candidate will learn and apply cutting-edge technologies the lab has developed to genes that currently lack scalable functional assays.
We are looking for an experienced scientist who has performed substantial lab-based research in genomics, genetics, molecular biology, stem cell biology, bioengineering, cancer biology, cell biology, or a related area. In-depth experience with current molecular biology methods, cell culture, and omics data analysis will prove highly beneficial. Familiarity with standard molecular biology methods is required, though specific experience with genome editing is unnecessary.
Considerable flexibility and support will be given for skills development and for proposing future lines of study. The successful applicant will benefit highly from the thriving research environment of the lab, the broader Crick community, and the Institute’s excellent scientific technology platforms (STPs).
To see the complete job description click here.
To see more about team/Group Leader click here.
Key Responsibilities
As an SLRS at the Crick, you will:
• Manage day to day lab operations
• Conduct research using cutting-edge technologies
• Analyse large experimental data sets
• Develop your own skills and propose future lines of study
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here:
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
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