We are seeking an experienced Operational Excellence Manager to join our Irvine Operations Team. You will lead Operational Excellence (OpEx) activities at the Irvine site which includes coordinating OpEx-related initiatives at the site, building OpEx project portfolio, driving Life Science Production System deployment (LSPS) according to global guidelines, managing resources, driving project execution, and implementing best practices and knowledge transfer across the organization. The ideal candidate should have a proven track record in implementing and inspiring an organization for daily continuous improvement using their knowledge of lean manufacturing. The Role: Partnerships and collaboration Act as main Point of Contact (POC) for all OpEx-related activities at the site and be a key part of the site Senior Leadership teamCollaborate with ISCO Excellence Execution project managers to coordinate project executions at the siteAct as site link to the ISCO Excellence PMO & Analytics function to provide inputs supporting e.g. standardized reports of savings and project progressDrive the ISCO Excellence LS Production System roll-out plan for the site, and collaborate with external partners & global team (e.g., support with implementation of specific tools, coaching, progress tracking, culture building)Collaborate with ISCO Academy to support building and delivering OpEx learning curriculum Collaborate with Smart Manufacturing team supporting the implementation of digital tools Site performance management Work together with the site leadership team to jointly define the site master plan (including LS Production System development plan to targeted future state in terms of next levels and/or certification) and to provide status updates on OpEx-related topics (e.g., project progress)Collect, analyze, and report data of current OpEx-related projects to the site leader (either own reports or insights provided by PMO & Analytics function on basis of collected data)Ensure definition and implementation of governance aspects incl. solid project charters & execution plans for each OpEx project with appropriate risk management Portfolio management, capability steering and knowledge transfer Build the OpEx project portfolio for the site to achieve site targets (safety, quality, supply, people & cost) and prioritize within OpEx project portfolio as part of the site leadership teamDrive specific projects at the siteEnsure resource availability for project execution and manage belt resources at the site assuring that site master plan targets / expected impact is achievedImplement best practices from other OpEx teams, and communicate own successes with other local OpEx and ISCO Excellence as well as the communities of excellenceBridge knowledge gaps in projects by requesting and managing/developing additionally required capabilities Who you are: Wealth of demonstrated track record in site operations preferred with experience in process/product engineering and in implementing improvement initiatives with impactful results, preferably in a leading positionPractical Lean Six Sigma experienceExperience in deployment of holistic production systems preferredIndustrial engineering/ supply chain/business administration degreebackgroundLean Six Sigma Belt certification required, black belt certification preferredProject Management certification preferredStrong interpersonal and communication skills, results-driven mentality, experience in leading teams (leading without authority), capable to zoom in and out (big picture and detail mindset)Ability to partner with a leadership team to refine goals and translate into an overall initiative plan