Research Associate in Improving Cerebral Blood Flow in Vascular Dementia, Manchester
Client:
The University of Manchester
Location:
Manchester, United Kingdom
Job Category:
Other
EU work permit required:
Yes
Job Reference:
88fb700c3726
Job Views:
8
Posted:
02.04.2025
Expiry Date:
17.05.2025
Job Description:
An exciting opportunity exists to carry out a BHF funded 3-year postdoctoral project to determine the effectiveness of a novel treatment option for hypertension-induced vascular dementia. The position will be in the Microvascular@Manchester group (microvascularmanchester.com) under the guidance of Dr Harry Pritchard and Professor Adam Greenstein, but also Professor Stuart Allan and Dr Ingo Schiessl of the Brain Inflammation Group (braininflamelab.org). The post will be based within the Division of Cardiovascular Sciences at the University of Manchester and the Geoffrey Jefferson Brain Research Centre.
The research follows on from the recent work from the Microvascular@Manchester group into the pathways underlying the reduction in cerebral blood flow in hypertension-induced vascular dementia (https://www.pnas.org/doi/10.1073/pnas.2307513120). The appointed person will work with cerebral arteries from a model of hypertension-induced cognitive decline, using both ex vivo and in vivo approaches. The goal is to determine if restoring ion channel activity in pail artery smooth muscle cells will improve arterial diameter control, cerebral blood flow, and cognitive function. This research will utilise electrophysiology of freshly dissociated vascular smooth muscle cells from cerebral arteries, as well as native small artery calcium imaging and pressure myography. Additionally, in vivo approaches to measure cerebral blood flow will use cutting-edge technologies including functional ultrasound and multi-photon imaging. Cognitive function will be determined using established behavioural tests. For candidates who do not have a background in all of the techniques, full training will be provided. The successful post-doctoral researcher will also be given fantastic opportunities to collaborate on other projects within the lab and/or within The Manchester British Heart Foundation Centre of Research Excellence.
What you will get in return:
* Fantastic market leading Pension scheme
* Excellent employee health and wellbeing services including an Employee Assistance Programme
* Exceptional starting annual leave entitlement, plus bank holidays
* Additional paid closure over the Christmas period
* Local and national discounts at a range of major retailers
As an equal opportunities employer, we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation, and transgender status. All appointments are made on merit.
Our University is positive about flexible working; you can find out more here.
Hybrid working arrangements may be considered.
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.
Any recruitment enquiries from recruitment agencies should be directed to People.Recruitment@manchester.ac.uk.
Any CVs submitted by a recruitment agency will be considered a gift.
Enquiries about the vacancy, shortlisting and interviews:
Name: Dr Harry Pritchard
General enquiries:
Email: People.recruitment@manchester.ac.uk
This vacancy will close for applications at midnight on the closing date.
Please see the link below for the Further Particulars document which contains the person specification criteria.
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