This position offers the opportunity to impact a growing portfolio of targeted therapies in a fast-paced and innovative research environment.
Our client is searching for a dynamic Associate Biology Scientist with experience interrogating cellular and molecular mechanisms as they relate to kinase target pathway modulation, off-target liabilities, and resistance.
Responsibilities:
* Independently develop, optimize, and proactively troubleshoot cellular screening assays.
* Responsible for generating, processing, interpreting, and presenting data in cross-functional team meetings.
* Proactively employ cell and molecular biology techniques, including gene targeting approaches and small molecule inhibition, to dissect mechanism of action.
* Independently design, execute, and document experiments to evaluate target dependency, off-target liabilities, phenotypic responses, and identifying resistance mechanisms.
* Regularly share and present data with team members.
Requirements / Qualifications:
* MS/BS in oncology, cellular biology, molecular biology, or related discipline with 1+ years of industry or relevant research experience is required.
* Experience in developing and optimizing cell-based assays in multiple platforms (for example CTG, HTRF, AlphaLISA, FC, Jess-WB, NanoBret, Nanostring).
* Experience with different molecular and cellular biology techniques (such as Western Blot).
* Experience with genome editing (CRISPR or si/shRNA) for engineering cell line models is a plus.
* Familiar with tumor models and establishing PK/PD/efficacy relationships and delivering PD readouts by western blots for in vivo tumor models.
* Experience with standard software analytical tools, xlsx, Prism, or other synergy software.
* Strong oral and written communication skills, as well as excellent documentation and organizational skills.
* A team player who listens effectively, invites response, and discussion.
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